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M94A2478.TXT
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1994-10-25
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Document 2478
DOCN M94A2478
TI Sperm parameters in HIV-1 infected patients.
DT 9412
AU Rossi T; Mazzilli F; D'Offizi G; Rosso R; Pinter E; Sarandrea N; Dondero
F; Aiuti F; 5th Medical Clinic Univ. of Rome La Sapienza.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):295 (abstract no. PC0107). Unique
Identifier : AIDSLINE ICA10/94370097
AB OBJECTIVE: Semen is considered to be an important vehicle in HIV
transmission. In our study we performed a longitudinal study of semen
parameters in HIV infected patients and in high risk group to identify
functional alterations of sperm in HIV+ patients and to establish
whether these could precede seroconversion. METHODS: We selected 16 HIV+
patients (4 CDC II, 4 CDC III, 8 CDC IVC2), 36 high risk seronegative
for HIV subjects, 30 potential semen donors. Semen analysis, the
hypoosmotic swelling test, the neutral red test and seminal plasma
biochemical analysis were performed according to WHO standards. RESULTS:
85% of HIV+ patient showed an alteration of the sperm kinetic properties
(44% of high risk subjects). Viscosity is increased in about 50% of HIV+
patients compared to 25% of high risk subjects. In both group, HIV+
patients and high risk subjects there was a significant increase of the
percentage of leukocytes and prevalence of peroxidase positive cells
(high risk subjects). 44% of HIV+ (22% of high risk subjects) showed
high level of spermiophage cells. DISCUSSION AND CONCLUSIONS: Physical
seminal parameters in HIV-1 infected patients are modified according to
CDC stage. Our preliminary data indicate: 1) increased viscosity is
probably due to the phlogosys of the adnexal glands of the genital tract
even in asymptomatic patients; 2) early failure of epididymal function
and 3) an increased level of spermiophage cells perhaps involved in the
sexual transmission of HIV-1.
DE Human HIV Infections/*TRANSMISSION HIV Seropositivity *HIV-1
Longitudinal Studies Male Semen/CHEMISTRY/CYTOLOGY
Spermatozoa/*PHYSIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).